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A longitudinal study of pulmonary function after stem cell transplantation, from childhood to young adulthood
Author(s) -
Frisk Per,
Arvidson Johan,
Hedenström Hans
Publication year - 2012
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.23183
Subject(s) - medicine , dlco , spirometry , pulmonary function testing , diffusing capacity , lung volumes , transplantation , vital capacity , lung , cardiology , gastroenterology , surgery , lung function , asthma
Background Impairment of pulmonary function after stem cell transplantation (SCT) in childhood has been reported before. However, long‐term longitudinal studies are scarce. Procedure We measured lung volumes and performed dynamic spirometry serially in 18 patients after SCT. At the last investigation, a median of 18.2 years after SCT, the patients were compared with 18 matched controls. The diffusing capacity (DLCO) was only compared cross‐sectionally. Results There was a significant increase in the prevalence of restrictive lung disease (RLD, total lung capacity <80% of that predicted) from 7% (1/14) before SCT to 28% (5/18) 5 years after SCT, and 61% (11/18) a median of 18.2 years after SCT ( P = 0.002). In comparison, none of the controls had RLD (61% vs. 0%, P = 0.001). Before SCT, no patient had obstructive lung disease (OLD, forced expiratory volume in 1 sec/vital capacity <70). OLD was found in one of 18 patients (6%) 5 years after SCT but in none of the patients a median of 18.2 years after SCT. Three of the controls had OLD ( P = 0.25). Eleven patients had diffusion impairment (DLCO <80% of that predicted), as opposed to none of the controls ( P = 0.001). The DLCO corrected for alveolar volume was decreased in only two patients. Conclusion We documented an increase in the prevalence of RLD, but not of OLD, after SCT. At the last investigation, only two patients had diffusion impairment after correction for alveolar volume. Pediatr Blood Cancer 2012; 58: 775–779. © 2011 Wiley Periodicals, Inc.