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Reduced bone mineral density in adult patients with Langerhans cell histiocytosis
Author(s) -
Makras Polyzois,
Terpos Evangelos,
Kanakis George,
Papatheodorou Athanasios,
Anastasilakis Athanasios D.,
Kokkoris Panagiotis,
Kaltsas Gregory A.
Publication year - 2012
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.23166
Subject(s) - medicine , langerhans cell histiocytosis , bone mineral , histiocytosis , histiocytosis x , pathology , osteoporosis , disease
This retrospective study evaluated bone mineral density (BMD) and bone turnover in adults with LCH. Twenty‐five adult patients and 25 matched controls were evaluated with BMD measurement and indices of bone metabolism. A BMD value below the expected range for age (Z‐score ≤ − 2.0) was found in 20% of patients; in particular, all postmenopausal women and men over 50‐years had either osteoporosis or osteopenia. Patients with active disease had significantly lower Z‐scores compared to patients with inactive disease and controls. Reduced bone turnover was found in all 14 patients treated with chemotherapy. No fractures due to osteoporosis were identified during 305.15 patient‐years of follow‐up. Pediatr Blood Cancer 2012; 58: 819–822. © 2011 Wiley Periodicals, Inc.