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Opsoclonus‐myoclonus and anti‐Hu positive limbic encephalitis in a patient with neuroblastoma
Author(s) -
Morales La Madrid Andres,
Rubin Charles M.,
Kohrman Michael,
Pytel Peter,
Cohn Susan L.
Publication year - 2012
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.23131
Subject(s) - medicine , neuroblastoma , limbic encephalitis , encephalitis , myoclonus , opsoclonus , pediatrics , pathology , immunology , psychiatry , virus , genetics , biology , cell culture
Opsoclonus‐myoclonus syndrome (OMS) is seen in 2–3% of children with neuroblastoma and is believed to be caused by an autoimmune process elicited by the tumor. Although long‐term neurologic sequelae are common in children with OMS, limbic encephalitis has not previously been reported. We report a child who developed limbic encephalitis associated with anti‐Hu antibodies, 6 years after her initial diagnosis of neuroblastoma and OMS. This case demonstrates that patients with neuroblastoma and OMS are at risk for developing new paraneoplastic symptoms years after their original diagnosis and emphasizes the need for careful long‐term follow‐up. Pediatr Blood Cancer 2012; 58: 472–474. © 2011 Wiley Periodicals, Inc.