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Piperacillin/tazobactam versus cefozopran for the empirical treatment of pediatric cancer patients with febrile neutropenia
Author(s) -
Ichikawa Mizuho,
Suzuki Daisuke,
Ohshima Junjiro,
Cho Yuko,
Kaneda Makoto,
Iguchi Akihiro,
Ariga Tadashi
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.23106
Subject(s) - medicine , piperacillin/tazobactam , neutropenia , blood cancer , pediatric cancer , febrile neutropenia , tazobactam , piperacillin , antibiotics , cancer , chemotherapy , genetics , biology , bacteria , microbiology and biotechnology , pseudomonas aeruginosa
Background The aim of this study was to evaluate the efficacy and safety of piperacillin/tazobactam (PIP/TAZO) and cefozopran (CZOP) monotherapy in pediatric cancer patients with febrile neutropenia (FN). Procedure A total of 119 febrile episodes in 49 neutropenic pediatric cancer patients (20 females and 29 males) with a median age of 6.8 years (range, 0.3–18.4 years) received randomized treatment either with PIP/TAZO 125 mg/kg every 8 hr or CZOP 25 mg/kg every 6 hr. Clinical response was determined at completion of therapy. Durations of fever and neutropenia, the need for modification of the therapy, and mortality rates were compared between the two groups. Results The frequency of success without modification of treatment was not significantly different between PIP/TAZO (59.6%) and CZOP (53.2%). Durations of fever and antibiotic therapy did not differ between the treatment groups, and no major side effects were observed in either group. Conclusions PIP/TAZO and CZOP monotherapy were both effective and safe for the initial empirical treatment of pediatric cancer patients with FN. Pediatr Blood Cancer 2011; 57: 1159–1162. © 2011 Wiley Periodicals, Inc.