Premium
Carboplatin‐based chemotherapy and surgery: A cost effective treatment strategy for malignant extracranial germ cell tumours in the developing world
Author(s) -
Hendricks Marc,
Davidson Alan,
Pillay Komala,
Desai Farieda,
Millar Alastair
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.23055
Subject(s) - medicine , carboplatin , chemotherapy , germ cell , germ cell tumors , blood cancer , cisplatin , oncology , radiology , surgery , cancer , biochemistry , chemistry , gene
Abstract Nineteen children with malignant extracranial germ cell tumours (MEGCT), were treated at our institution with a combination of carboplatin‐based chemotherapy and surgery from 1992 to 2008. Seventeen are long term survivors. Chemotherapy was administered on an outpatient basis and required no monitoring of GFR or auditory function. There were no deaths from toxicity or infection. Blood product use was low. Carboplatin‐based therapy achieved excellent results in our patient population and constitutes more than a US $1,800 saving per patient compared to regimens containing cisplatin. This has application in resource limited settings. Pediatr Blood Cancer 2011;57:172–174. © 2011 Wiley‐Liss, Inc.