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Siblings presenting with progressive congenital aleukemic leukemia cutis
Author(s) -
Agrawal Anurag K.,
Guo Hua,
Golden Carla
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.23053
Subject(s) - leukemia cutis , medicine , leukemia , myeloid leukemia , myeloid , pathology , dermatology , immunology
Congenital leukemia is infrequent, occurring in <1% of pediatric leukemia patients, and mainly of myeloid lineage. Twenty‐five to 30% of congenital leukemia cases present with cutaneous leukemic infiltrates. Rarely, infants will have aleukemic leukemia cutis, presenting with leukemic skin lesions but without systemic symptoms or bone marrow involvement. Few cases of congenital aleukemic leukemia cutis have been reported in the literature. The course of disease is variable as cases of spontaneous resolution have been described. Here we present the first report of siblings with progressive congenital aleukemic leukemia cutis, both treated successfully with myeloid leukemia chemotherapy. Pediatr Blood Cancer 2011; 57: 338–340. © 2011 Wiley‐Liss, Inc.