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Systemic Mastocytosis in a Child With t(8;21) Acute Myeloid Leukemia
Author(s) -
Mahadeo Kris M.,
Wolgast Lucia,
McMahon Christine,
Cole Peter D.
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.23026
Subject(s) - medicine , systemic mastocytosis , blood cancer , myeloid leukemia , asymptomatic , chemotherapy , bone marrow , myeloid , leukemia , oncology , cancer
Mastocytosis is primarily limited to the cutaneous variant in pediatric patients. Systemic mastocytosis (SM) has been associated with t(8;21) acute myeloid leukemia (AML) in adults. We provide the first report of a child with t(8;21) AML, diagnosed with asymptomatic SM following four cycles of chemotherapy. Unlike most adults with SM/AML, she was not found to have a c‐KIT (D816V) mutation. SM persisted in the bone marrow after completion of chemotherapy, and her AML relapsed 9 months off‐treatment. Although she achieved a second remission, mastocytosis persists in the marrow. Pediatric patients with t(8;21) AML/SM may represent a high‐risk group despite favorable cytogenetics. Pediatr Blood Cancer 2011; 57: 684–687. © 2011 Wiley‐Liss, Inc.