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Disseminated intravascular coagulation due to IgM‐mediated autoimmune hemolytic anemia
Author(s) -
Bleakly N. Teresa,
Fontaine Magali J.,
Pate Lisa L.,
Sutherland Scott M.,
Jeng Michael
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.23024
Subject(s) - medicine , hemolysis , autoimmune hemolytic anemia , disseminated intravascular coagulation , hemolytic anemia , gangrene , immunology , coagulation , cold agglutinin disease , cold agglutinin , anemia , pathology , antibody
Disseminated intravascular coagulation (DIC) due to red cell hemolysis has been previously attributed to transfusion‐related hemolytic reactions, but not to autoimmune hemolytic anemia. We report a case of DIC in a child with complement‐fixing IgM‐mediated cold‐agglutinin autoimmune hemolysis, which resulted in arterial thrombosis and gangrene of the upper and lower extremities. Pediatr Blood Cancer 2011; 57: 329–331. © 2011 Wiley‐Liss, Inc.