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Antiphospholid antibody syndrome and Hb E/Beta thalassemia disease post‐allogeneic stem cell transplantation
Author(s) -
Sirachainan gnuch,
Pakakasama Samart,
Hongeng Suradej,
Chuansumrit Ampaiwan,
Tuntiyatorn Lojana,
Vilaiyuk Soamarat
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.23020
Subject(s) - medicine , azathioprine , methylprednisolone , beta thalassemia , transplantation , prednisolone , gastroenterology , thalassemia , autoantibody , antibody , hematopoietic stem cell transplantation , stem cell , surgery , disease , immunology , biology , genetics
Abstract We report a 10‐year‐old male with Hb E/Beta thalassemia disease who developed chronic graft‐versus‐host disease (cGVHD) of antiphospholipid antibody syndrome after successful allogeneic stem cell transplantation (SCT). He exhibited a recurrent ischemic stroke on day 368 post‐SCT while on cyclosporine A, azathioprine, and prednisolone. The immunosuppressive agents were switched to pulse methylprednisolone, tacolimus, mycophenolate mofetil, and enoxaparin, but the patient was more confused. An additional plasma exchange which was aimed at the immediate removal of autoantibody was performed with a good response. The symptoms rapidly disappeared except for the complex partial seizure which persisted until seven years post‐SCT. Pediatr Blood Cancer 2011;57:153–156. © 2011 Wiley‐Liss, Inc.