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Assessment of late cardiotoxicity of pirarubicin (THP) in children with acute lymphoblastic leukemia
Author(s) -
Shimomura Yasuto,
Baba Reizo,
Watanabe Arata,
Horikoshi Yasuo,
Asami Keiko,
Hyakuobuyuki,
Iwai Asayuki,
Matsushita Takeshi,
Yamaji Kazutaka,
Hori Toshinori,
Tsurusawa Masahito
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.23012
Subject(s) - medicine , pirarubicin , cardiotoxicity , asymptomatic , anthracycline , cumulative dose , cardiology , lymphoblastic leukemia , chemotherapy , leukemia , cancer , breast cancer
Background Pirarubicin (tetrahydropyranyl‐adriamycin: THP) is a derivative of doxorubicin with reportedly less cardiotoxicity in adults. However no studies of cardiotoxicity in children treated with THP have been reported. This study was performed to assess the THP‐induced cardiotoxicity for children with acute lymphoblastic leukemia (ALL). Patients and Methods This study comprised 61 asymptomatic patients aged from 7.6 to 25.7 years old. Median follow‐up time after completion of anthracycline treatment was 8.1 years (range: 1.7–12.5). The cumulative dose of THP ranged from 120 to 740 mg/m 2 with a median of 180 mg/m 2 . Patients underwent electrocardiogram (ECG), echocardiography, the 6‐min walk test (6MWT), and measurements of serum brain natriuretic peptide (BNP) before and after exercise. Results All subjects showed normal left ventricular function assessed by echocardiography. Ventricular premature contraction in Holter ECG and reduced exercise tolerance in the 6MWT were detected in 2/46 (3.3%) and 5/41(12.2%), respectively. Abnormal BNP levels were detected in 6/60 (10%) both before and after exercise. The cumulative dose of THP was significantly correlated with BNP levels after exercise (r = 0.27, P = 0.03), but not with any other cardiac measurements. Further analysis revealed that subjects with a high cumulative dose ≧300 mg/m 2 had significantly higher BNP levels after exercise compared with subjects with a low cumulative dose <300 mg/m 2 ( P = 0.04). Conclusions No significant cardiac dysfunction was detected in long‐term survivors who received THP treatment. The use of post‐exercise BNP level to indicate high cardiotoxicity risk should be verified by further study. Pediatr Blood Cancer 2011; 57: 461–466. © 2011 Wiley‐Liss, Inc.