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Successful bone marrow transplantation in a pediatric patient with chronic myeloid leukemia from a HLA‐identical sibling selected by preimplantation HLA testing
Author(s) -
Goussetis Evgenios,
Constantoulakis Pantelis,
Kitra Vasiliki,
Peristeri Ioulia,
Mastrominas Minas,
Baka Margarita,
Papadimitropoulos Miltiadis,
Karamolegos Christos,
Paisiou Anna,
VasilatouKosmidis Helen,
Graphakos Stelios
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.23007
Subject(s) - medicine , myeloid leukemia , sibling , transplantation , human leukocyte antigen , bone marrow transplantation , bone marrow , leukemia , histocompatibility testing , imatinib , immunology , oncology , psychology , developmental psychology , antigen
We report successful bone marrow transplantation in an 11‐year‐old male with chronic myeloid leukemia from his HLA‐identical sibling selected by preimplantation HLA testing. Because collection of cord blood failed, the transplantation was performed when the donor reached the age of 19 months, and sufficient bone marrow could be harvested safely. The patient was BCR/ABL negative at the time of transplantation after complete molecular response to imatinib. Currently, 16 months post‐transplantation he is well and in complete molecular remission. This report describes preimplantation HLA‐genotyping to deliver a matched sibling donor for successful transplantation of a malignant disorder. Pediatr Blood Cancer 2011; 57: 345–347. © 2011 Wiley‐Liss, Inc.