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Comparison of permanent hair loss in children with standard risk PNETS of the posterior fossa following radiotherapy alone or chemotherapy and radiotherapy after surgical resection
Author(s) -
Rogers Susanne,
Donachie Paul,
Sugden Elaine,
Sharpe Geoffrey,
English Martin,
Robinson Kath,
Saran Frank
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22992
Subject(s) - medicine , medulloblastoma , hair loss , radiation therapy , chemotherapy , surgery , posterior fossa , posterior cranial fossa , late effect , dermatology , cancer research
Hair loss was compared between surgery followed by craniospinal radiotherapy (CSRT) or chemotherapy then CSRT (C‐CSRT) for medulloblastoma. The proportion of patients exhibiting hair loss in the cranial field was 70.0% (C‐CSRT) versus 30.0% (CSRT) (95% CI: 14.7% to 58.9%; P = 0.002). The C‐CSRT group also experienced more virtual/complete hair loss over the posterior fossa boost. Age was a significant contributor to hair loss in the cranial field. Persistent significant hair loss is an under‐reported late effect of treatment that could influence quality of survival and should be considered in future trial design. Pediatr Blood Cancer 2011; 57: 1074–1076. © 2011 Wiley‐Liss, Inc.