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Platelet disorders in children: A diagnostic approach
Author(s) -
Israels Sara J.,
Kahr Walter H.A.,
Blanchette Victor S.,
Luban Naomi L.C.,
Rivard Georges E.,
Rand Margaret L.
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22988
Subject(s) - medicine , platelet , platelet disorder , blood cancer , mucocutaneous zone , flow cytometry , medical diagnosis , blood platelet disorders , pathology , immunology , cancer , platelet aggregation , disease
The investigation of children with suspected inherited platelet disorders is challenging. The causes of mucocutaneous bleeding are many, and specialized testing for platelet disorders can be difficult to access or interpret. An algorithm developed for the investigation of suspected platelet disorders provides a sequential approach to evaluating both platelet function abnormalities and thrombocytopenia. Investigation begins with a clinical evaluation and laboratory testing that is generally available, including platelet counting, peripheral blood cell morphology, and aggregometry. Based on results of initial investigations, the algorithm recommends specialized testing for specific diagnoses, including flow cytometry, immunofluorescence microscopy, electron microscopy, and mutational analysis. Pediatr Blood Cancer 2011;56:975–983. © 2011 Wiley‐Liss, Inc.