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Late effects in childhood cancer survivors: A review with a framing effect bias?
Author(s) -
Fryer Christopher
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22975
Subject(s) - medicine , life expectancy , adverse effect , childhood cancer , malignancy , pediatrics , cancer , anthracycline , population , environmental health , breast cancer
Most publications report the adverse (negative) health issues in childhood cancer survivors. Presenting information to the newly diagnosed patient in a positive manner is advocated, while noting that recurrence is the most likely adverse event. Re‐analysis of population‐based studies on life‐threatening toxicities from Nordic, Dutch, United Kingdom, French, Italian, and N. American publications shows that 5‐year survivors have a near normal life expectancy, 75% have no severe or life‐threatening treatment related toxicity and 87% remain free of a second malignancy. Children who received radiation or anthracycline >250–300 mg/m 2 are at greatest risk for treatment related life‐threatening toxicities. Pediatr Blood Cancer 2011; 57: 1100–1103. © 2011 Wiley Periodicals, Inc.