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Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: Evidence for genomic instability
Author(s) -
Chandrakasan Shanmuganathan,
Ye Christine J.,
Chitlur Meera,
Mohamed Anwar N.,
Rabah Raja,
Konski Andre,
Heng Henry H. Q.,
Savaşan Süreyya
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22929
Subject(s) - medicine , genome instability , lymphoma , stem cell , peripheral blood , chromosome instability , pathology , cancer research , cancer , radiation therapy , oncology , immunology , biology , chromosome , dna damage , dna , genetics , gene
Secondary malignancies (SMs) in Hodgkin lymphoma (HL) are thought to be related to exposure to alkalating agents, topoisomerase II inhibitors and ionizing radiation, and tend to occur a decade after initial therapy. We report a 14 year old autistic male, who developed malignant fibrous histiocytoma (MFH) two years after autologous stem cell transplantation for advanced stage HL. The MFH and post‐surgical reactive tissues exhibited multiple clonal abnormalities. In addition, PHA‐stimulated peripheral blood lymphocytes showed increased frequency of non‐clonal chromosomal aberrations. The potential role of genomic instability in early onset of SM in our patient is discussed. Pediatr Blood Cancer 2011;56:1143–1145. © 2010 Wiley‐Liss, Inc.