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Tumor‐initiating cells and tumor vascularization
Author(s) -
Zhang LiZhi,
Zhang ChangQing,
Yan ZhenYu,
Yang QingCheng,
Jiang Yao,
Zeng BingFang
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22886
Subject(s) - crosstalk , medicine , stromal cell , hypoxia (environmental) , cancer research , tumor progression , dormancy , biology , cancer , chemistry , physics , organic chemistry , oxygen , optics , germination , botany
Tumor‐initiating cells (TICs) with stem‐like cell properties initiate and sustain progressive growth, resulting in a heterogeneous tumor mass. The survival and growth of tumors rely on the development of a vasculature to provide nutrients and oxygen. Crosstalk between TICs and vascularization may be one of the central players in the initiation, long‐term maintenance, and progression of tumors. This review surveys current evidence concerning the crosstalk that occurs in tumor/stromal interactions, including genetic change, vascular niche, hypoxia, and dormancy of tumors. A better understanding of this crosstalk might help provide the basis for developing more effective therapeutic drug targets. Pediatr Blood Cancer 2011;56:335–340. © 2010 Wiley‐Liss, Inc.