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Mucoepidermoid carcinoma of the lung arising at the primary site of a bronchogenic cyst: Clinical, cytogenetic, and molecular findings
Author(s) -
Brassesco María Sol,
Valera Elvis Terci,
Lira Régia Caroline Peixoto,
Torres Lídia Alice Gomes M.,
Scrideli Carlos Alberto,
Elias Jorge,
Teixeira Sara Reis,
Tone Luiz Gonzaga
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22872
Subject(s) - mucoepidermoid carcinoma , medicine , pathology , lung , carcinogenesis , chromosomal translocation , lung cancer , karyotype , carcinoma , bronchogenic cyst , cyst , cancer , biology , gene , genetics , chromosome
Primary lung tumors are rare in children, and mucoepidermoid carcinoma (MEC) represents less than 10% of them. Additionally, MEC arising from bronchogenic cysts (BC) is particularly unusual. We describe the clinical and genetic findings on a MEC occurring within a previous location of a BC in an adolescent. This particular association has not been previously reported. The lesion revealed normal karyotype without the typical t(11;19)(q21;p13) translocation. Cyclin D1 overexpression (165‐fold increase) was demonstrated by real‐time PCR although FISH assessment showed normal hybridization at 11q13. Information on these unusual clinical presentations may present relevant insight on tumorigenesis of infrequent pediatric pulmonary tumors. Pediatr Blood Cancer 2011;56:311–313. © 2010 Wiley‐Liss, Inc.