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Immunoglobulin abnormalities and effects of enzyme replacement therapy in children with Gaucher disease
Author(s) -
ArıkanAyyıldız Zeynep,
Yuce Aysel,
UsluKızılkan Nuray,
Demir Hülya,
Gurakan Figen
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22863
Subject(s) - medicine , enzyme replacement therapy , antibody , disease , blood cancer , immunoglobulin g , immunology , cancer
Abstract Hyperimmunoglobulinemia is documented in patients with Gaucher disease of all ages. We investigated the frequency of hyperimmunoglobulinemia in 12 pediatric patients with type I and III Gaucher disease and the effects of enzyme replacement therapy on these abnormalities. The incidence of hyperimmunoglobulinemia was 77%, 66%, and 60% at the diagnosis, before and after ERT, respectively. Immunoglobulin G abnormalities were the most commonly seen isotype abnormality. After enzyme replacement therapy normalization of IgA and IgM levels were recorded but decline in IgG levels was less likely to occur. This study indicated the higher frequency of hyperimmunoglobulinemia in pediatric Gaucher patients. Pediatr Blood Cancer 2011;56:664–666. © 2010 Wiley‐Liss, Inc.