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Vascular Endothelial Growth Factor A isoform mRNA expression in pediatric acute myeloid leukemia
Author(s) -
Kruizinga R.C.,
de Jonge H.J.M.,
Kampen K.R.,
Walenkamp A.M.E.,
de Bont E.S.J.M.
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22783
Subject(s) - gene isoform , vascular endothelial growth factor a , vascular endothelial growth factor , medicine , cancer research , angiogenesis , vegf receptors , messenger rna , myeloid leukemia , oncology , biology , genetics , gene
In AML high VEGFA protein expression correlates with poor overall and relapse‐free survival (OS/RFS). To date, the relevance of the various VEGFA isoforms is unclear. We determined VEGF121 , VEGF145 , VEGF148 , VEGF165 , VEGF183 , and VEGF189 mRNA expression in pediatric AML samples and investigated the relation between VEGFA isoform expression and clinicopatholologic characteristics and outcome. A significant co‐expression of VEGF121 , VEGF165 , VEGF183 , and VEGF189 isoforms was apparent (mean rho = 0.716, P < 0.0001). This co‐expression justifies measuring a single VEGFA isoform (e.g., 121, 165, 183, and 189) as representative expression of all VEGFA isoforms in future studies designed to determine the prognostic importance of VEGFA isoforms. Pediatr Blood Cancer 2011;56:294–297. © 2010 Wiley‐Liss, Inc.