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Chemoresistant hepatoblastoma in a patient with mosaic trisomy 18 treated with orthotopic liver transplantation
Author(s) -
Fernandez Karen S.,
Baum Rebecca,
Fung Bonita,
Yeager Nicholas,
Leonis Mike A.,
Wagner Lars M.,
Tiao Greg,
Ross Mary E.
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22768
Subject(s) - hepatoblastoma , medicine , transplantation , vincristine , liver transplantation , trisomy , chemotherapy , pathology , surgery , cyclophosphamide , biology , genetics
We present a 9‐month‐old male with mosaic trisomy 18 with a right hepatic lobe mass. The tumor was completely resected and identified as pure fetal histology hepatoblastoma but contained increased mitotic activity. Adjuvant chemotherapy consisted of cisplatin, vincristine, and 5‐fluorouracil. After the first and fourth cycles of chemotherapy, recurrent tumor developed. The patient underwent rescue orthotopic liver transplantation, and is currently alive without evidence of hepatoblastoma 28 months after transplantation. This report demonstrates the use of orthotopic liver transplantation in a child with mosaic trisomy 18 and hepatoblastoma. Pediatr Blood Cancer 2011;56:498–500. © 2010 Wiley‐Liss, Inc.