Acute megakaryoblastic leukemia with a four‐way variant translocation originating the  RBM15–MKL1  fusion gene | Zendy

Torres Lurdes | Zendy; Lisboa Susana | Zendy; Vieira Joana | Zendy; Cerveira Nuno | Zendy; Santos Joana | Zendy; Pinheiro Manuela | Zendy; Correia Cecília | Zendy; Bizarro Susana | Zendy; Almeida Marta | Zendy; Teixeira Manuel R. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Acute megakaryoblastic leukemia with a four‐way variant translocation originating the RBM15–MKL1 fusion gene

Author(s) -

Torres Lurdes,

Lisboa Susana,

Vieira Joana,

Cerveira Nuno,

Santos Joana,

Pinheiro Manuela,

Correia Cecília,

Bizarro Susana,

Almeida Marta,

Teixeira Manuel R.

Publication year - 2011

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.22765

Subject(s) - acute megakaryoblastic leukemia , chromosomal translocation , medicine , myeloid leukemia , fusion gene , fusion transcript , karyotype , leukemia , gene , acute leukemia , chromosome , cancer research , microbiology and biotechnology , genetics , immunology , biology

Acute megakaryoblastic leukemia (AMKL) with t(1;22)(p13;q13) is a subset of acute myeloid leukemia (AML) representing <1% of all cases and about 70% of pediatric AMKL in the first year of life. We present a case of a 7‐month‐old female in whom the bone marrow karyotype showed the derivative chromosome der(22)t(1;22)(p13;q13). The RBM15–MKL1 fusion transcript was detected by RT‐PCR and confirmed by sequencing analyses. FISH analyses revealed the presence of the four‐way translocation t(1;22;17;18)(p13;q13;q22;q12). Pediatr Blood Cancer 2011;56:846–849. © 2011 Wiley‐Liss, Inc.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research