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Sequential acquisition of IgH and TCR rearrangements during the preleukemic phase of acute lymphoblastic leukemia in an adolescent patient
Author(s) -
Linden Tobias,
Furlan Ingrid,
Schwarz Stephan,
Stoehr Robert,
Niemeyer Charlotte M.,
Rossig Claudia
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22734
Subject(s) - clone (java method) , medicine , gene rearrangement , bone marrow , t cell receptor , acute lymphocytic leukemia , leukemia , monoclonal , cancer research , immunology , lymphoblastic leukemia , biology , genetics , gene , monoclonal antibody , t cell , antibody , immune system
Acute lymphoblastic leukemia (ALL) can be preceded by a prodromal phase of bone marrow failure. In serial trephine biopsies in a girl with acquired bone marrow hypoplasia, we have identified a monoclonal B‐cell precursor population characterized by a clone‐specific IgH‐FR3 gene rearrangement. Progression to ALL more than 4 months later was accompanied by acquisition of an additional T‐cell receptor rearrangement. Thus, hypoplastic pre‐ and overt leukemia share a common clonal origin. Prospective biobanking and extended molecular analysis can help to better understand the nature and sequence of genetic events during progression of a covert (pre)leukemic clone. Pediatr Blood Cancer 2011;56:301–303. © 2010 Wiley‐Liss, Inc.