Sequential acquisition of IgH and TCR rearrangements during the preleukemic phase of acute lymphoblastic leukemia in an adolescent patient | Zendy

Linden Tobias | Zendy; Furlan Ingrid | Zendy; Schwarz Stephan | Zendy; Stoehr Robert | Zendy; Niemeyer Charlotte M. | Zendy; Rossig Claudia | Zendy

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Sequential acquisition of IgH and TCR rearrangements during the preleukemic phase of acute lymphoblastic leukemia in an adolescent patient

Author(s) -

Linden Tobias,

Furlan Ingrid,

Schwarz Stephan,

Stoehr Robert,

Niemeyer Charlotte M.,

Rossig Claudia

Publication year - 2011

Publication title -

pediatric blood and cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.116

H-Index - 105

eISSN - 1545-5017

pISSN - 1545-5009

DOI - 10.1002/pbc.22734

Subject(s) - clone (java method) , medicine , gene rearrangement , bone marrow , t cell receptor , acute lymphocytic leukemia , leukemia , monoclonal , cancer research , immunology , lymphoblastic leukemia , biology , genetics , gene , monoclonal antibody , t cell , antibody , immune system

Acute lymphoblastic leukemia (ALL) can be preceded by a prodromal phase of bone marrow failure. In serial trephine biopsies in a girl with acquired bone marrow hypoplasia, we have identified a monoclonal B‐cell precursor population characterized by a clone‐specific IgH‐FR3 gene rearrangement. Progression to ALL more than 4 months later was accompanied by acquisition of an additional T‐cell receptor rearrangement. Thus, hypoplastic pre‐ and overt leukemia share a common clonal origin. Prospective biobanking and extended molecular analysis can help to better understand the nature and sequence of genetic events during progression of a covert (pre)leukemic clone. Pediatr Blood Cancer 2011;56:301–303. © 2010 Wiley‐Liss, Inc.

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