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Hemophagocytic lymphohistiocytosis associated with precursor B acute lymphoblastic leukemia
Author(s) -
Kelly Caitlin,
Salvi Sharad,
McClain Kenneth,
Hayani Ammar
Publication year - 2011
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22688
Subject(s) - medicine , pancytopenia , hemophagocytic lymphohistiocytosis , hematopoietic stem cell transplantation , lymphoblastic leukemia , leukemia , refractory (planetary science) , blood cancer , transplantation , immunology , pediatrics , cancer , bone marrow , physics , disease , astrobiology
We report a case of a child with precursor‐B acute lymphoblastic leukemia (ALL) who experienced refractory thrombocytopenia and massive splenomegaly during standard induction chemotherapy. He was diagnosed with hemophatocytic lymphohistiocytosis (HLH) during induction. Clinical and laboratory evaluation showed no evidence of infectious cause to HLH. Pancytopenia and HLH persisted after consolidation therapy even with remission from leukemia. After failure to control HLH with ALL‐directed therapy and HLH‐directed therapy, the patient underwent unrelated donor hematopoietic stem cell transplantation 8 months after diagnosis. He is 34 months post‐transplant and in remission from leukemia and HLH. Pediatr Blood Cancer 2011;56:658–660. © 2010 Wiley‐Liss, Inc.