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An unusual case of acute myeloid leukemia: Late isolated testicular relapse followed by isolated central nervous system relapse
Author(s) -
Grier David D.,
Eskew Andrew,
White Thomas,
McLean Thomas W.
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22666
Subject(s) - medicine , myeloid leukemia , central nervous system , bone marrow , chemotherapy , myeloid , pathology , oncology
Testicular relapse of acute myeloid leukemia without bone marrow involvement is a rare event. We describe a case of an 18‐year‐old male who had an isolated testicular relapse 86 months (7.2 years) from original diagnosis. He was treated with surgery only, without adjuvant therapy. The patient then developed central nervous system involvement 9 months later. Fluorescence in situ hybridization and immunohistochemistry were used to establish the diagnosis of a relapse rather than a new leukemic process. He was treated with intrathecal chemotherapy and systemic reinduction, followed by a stem cell transplant. This patient had a 7.2‐year period between original diagnosis and the testicular relapse of acute myeloid leukemia. Pediatr Blood Cancer. 2010;55:1231–1233. © 2010 Wiley‐Liss, Inc.