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Hemostatic management of an infant with severe hemophilia A and tetralogy of Fallot for cardiac bypass surgery
Author(s) -
Rodriguez Vilmarie,
Burkhart Harold M.,
Schmidt Kirstin A.,
Pruthi Rajiv K.
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22646
Subject(s) - medicine , tetralogy of fallot , hemostasis , cardiac surgery , cardiopulmonary bypass , surgery , cardiothoracic surgery , recombinant factor viia , cardiology , heart disease
We present the hemostatic management of severe hemophilia A of an infant with high risk of inhibitor development who underwent cardiac surgery for correction of tetralogy of Fallot. Continuous infusion of recombinant factor VIII resulted in good hemostasis during surgery and postoperatively. Unfortunately, the patient had inhibitor development 2 months after cardiothoracic surgery. Although cardiac surgery is successful, exposure to factor concentrates in severe hemophilia early in life might predispose a patient to inhibitor development. Pediatr Blood Cancer. 2010;55:1399–1401. © 2010 Wiley‐Liss, Inc.