Premium
MRI changes associated with vigabatrin treatment mimicking tumor progression
Author(s) -
Yang Tong,
Pruthi Sumit,
Geyer J. Russell,
Ojemann Jeffrey G.
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22626
Subject(s) - vigabatrin , medicine , magnetic resonance imaging , tumor progression , radiology , epilepsy , cancer , psychiatry , anticonvulsant
Abstract Vigabatrin has been used as first‐line treatment of infantile spasms. Reversible cerebral MRI signal changes have been reported to be associated with vigabatrin treatments. We report a case of a 5‐month‐old female who, following resection of an anaplastic oligodendroglioma developed, while treated with vigabatrin for seizures, abnormal DWI and FLAIR MRI signal changes worrisome for tumor progression or recurrence. Discontinuation of vigabatrin led to reversal of the MRI changes. This report highlights the fact that vigabatrin treatment can mimic tumor progression on MRI and confound management of tumors associated with seizures in pediatric patients. Pediatr Blood Cancer. 2010;55:1221–1223. © 2010 Wiley‐Liss, Inc.