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Severe polyuria and polydipsia in hyponatremic‐hypertensive syndrome associated with Wilms tumor
Author(s) -
D'Angelo Paolo,
Catania Serena,
Zirilli Giusy,
Collini Paola,
Tropia Serena,
Perotti Daniela,
Terenziani Monica,
Spreafico Filippo
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22610
Subject(s) - polyuria , medicine , polydipsia , hyponatremia , hypokalemia , wilms' tumor , nephrectomy , renovascular hypertension , urology , endocrinology , kidney , diabetes mellitus
The combination of hyponatremia and renovascular hypertension is known as hyponatremic‐hypertensive syndrome (HHS) and so rarely described in children but associated with various kinds of occlusions of the renal artery. We describe two children who presented HHS with severe hypokalemia, polyuria, and polydipsia associated with Wilms tumor, which required treatment with an angiotensin‐converting enzyme inhibitor before nephrectomy. All HHS signs and symptoms resolved only following surgical resection of the tumor, allowing chemotherapy to be given. Pediatr Blood Cancer. 2010;55:566–569. © 2010 Wiley‐Liss, Inc.