Premium
Development of secondary T‐cell acute lymphoblastic leukemia in a child with hemophagocytic lymphohistiocytosis
Author(s) -
Shamsian Bibi Shahin,
Gharib Atoosa,
Rezaei Nima,
Esfahani Shadi Abdar,
Alavi Samin,
Goudarzipour Kourosh,
Arzanian Mohammad Taghi
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22578
Subject(s) - medicine , hemophagocytic lymphohistiocytosis , lymphoblastic leukemia , malignancy , pediatrics , sepsis , regimen , macrophage activation syndrome , leukemia , immunology , disease , arthritis
Hemophagocytic lymphohistiocytosis (HLH) is a severe life‐threatening disorder, characterized by hyperactivation of macrophages. A 12‐year‐old female was referred to our center; the diagnosis of HLH was made for the patient and immunosuppressive regimen was started. After a 2‐year follow‐up, the patient developed secondary T‐cell acute lymphoblastic leukemia (T‐ALL), confirmed by flow cytometric studies. Treatment was started based on T‐ALL protocol, but the patient died because of relapse and sepsis. This case highlights the issue of secondary malignancy following HLH and demonstrates the need for continued follow‐up in such patients. Pediatr Blood Cancer. 2010;55:725–726. © 2010 Wiley‐Liss, Inc.