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Refractory dilated cardiomyopathy associated with metastatic neuroblastoma
Author(s) -
Carlson Peter,
Jefferies John L.,
Kearney Debra,
Russell Heidi
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22569
Subject(s) - medicine , neuroblastoma , dilated cardiomyopathy , cardiomyopathy , refractory (planetary science) , blood cancer , oncology , heart failure , cancer , genetics , biology , cell culture , physics , astrobiology
A 2‐year‐old African American male presented with heart failure and an abdominal mass. Computerized tomography (CT) scan revealed a 7 cm adrenal lesion, confirmed as poorly differentiated neuroblastoma (NB). CT and meta‐iodobenzoguanidine (MIBG) scans identified multiple metastases, but cardiac MIBG imaging was absent. Cardiac ejection fraction (EF) was 8% with 7% shortening fraction. The patient underwent six cycles of chemotherapy and investigational immunotherapy. Cardiac function improved to 26% EF. However, the tumor proved unresponsive to treatment. The patient died from stage IV congestive heart failure (CHF) and progressive NB. Autopsy confirmed dilated cardiomyopathy with endocardial fibroelastosis. Pediatr Blood Cancer. 2010;55:736–738. © 2010 Wiley‐Liss, Inc.
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