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Susceptibility to invasive bacterial infections in children with sickle cell disease
Author(s) -
Battersby Anna J.,
KnoxMacaulay Huxley H.M.,
Carrol Enitan D.
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22461
Subject(s) - medicine , streptococcus pneumoniae , disease , immunology , haemophilus influenzae , antibiotics , dysfunctional family , immunization , pneumococcal disease , pediatrics , antibody , microbiology and biotechnology , biology , clinical psychology
Individuals with sickle cell disease (SCD) demonstrate an increased susceptibility to invasive bacterial infections (IBI). The most common organisms causing IBI are Streptococcus pneumoniae , nontyphi Salmonella species and Haemophilus influenzae type b (Hib). IBI are the most common causes of death in children below 5 years of age with SCD. Increased susceptibility to IBI is because of several factors including dysfunctional antibody production and opsonophagocytosis as well as defective splenic clearance. Early diagnosis of Hib and pneumococcal infections combined with antibiotic prophylaxis and immunization programs, could lead to significant improvements in mortality, especially in Africa. Pediatr Blood Cancer. 2010;55:401–406. © 2010 Wiley‐Liss, Inc.