Premium
Effect of hemodialysis on the plasma levels of clofarabine
Author(s) -
Steinherz Peter G.,
Shukla Neerav,
Kobos Rachel,
Latcha Sheron
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22458
Subject(s) - clofarabine , hemodialysis , medicine , dialysis , urology , gastroenterology , leukemia , cytarabine
Clofarabine, a nucleoside analogue for treatment of relapsed leukemia, is 50–60% excreted in urine. Clofarabine has not been studied in patients on hemodialysis. We measured levels in one patient in acute renal failure. Prior to dialysis, 43 hr after a 40 mg/m 2 infusion, plasma concentration was 139 ng/ml. One hour after begining hemodialysis, a 20 mg/m 2 infusion began. Plasma concentrations were 84.2, 81.1, and 88.0 ng/ml while the dialysis and clofarabine infusion occurred simultaneously. Post‐dialysis, while the clofarabine was still infusing, the level was 95.8 ng/ml. Hemodialysis does decrease clofarabine levels, but given its large volume distribution, hemodialysis may not be effective for clofarabine overdose. Pediatr Blood Cancer 2010;55:196–198. © 2010 Wiley‐Liss, Inc.