Premium
Polymyxin‐direct hemoperfusion for sepsis‐induced multiple organ failure
Author(s) -
Hirabayashi Koichi,
Shiohara Masaaki,
Saito Shoji,
Tanaka Miyuki,
Yanagisawa Ryu,
Tsuruta Goro,
Fukuyama Tetsuhiro,
Hidaka Yoshihiko,
Nakazawa Yozo,
Shimizu Takashi,
Sakashita Kazuo,
Koike Kenichi
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22447
Subject(s) - medicine , hemoperfusion , sepsis , polymyxin , polymyxin b , intensive care medicine , antibiotics , microbiology and biotechnology , hemodialysis , biology
We report a case of multiple organ failure caused by the Bacillus cereus infection during acute lymphoblastic leukemia therapy, who was treated successfully. A 15‐year‐old male developed ( B. cereus ) sepsis on the 19th day after chemotherapy initiation. Polymyxin‐direct hemoperfusion for septic shock was started, followed by continuous hemodiafiltration. His condition improved after starting the hemoperfusion. At the onset of sepsis, elevated levels of serum inflammatory cytokines, anti‐inflammatory cytokines, and plasminogen‐activator inhibitor complex‐1 were observed. Serum levels of these cytokines and bioactive substances decreased after blood purification therapy, which correlated with the improvement of clinical symptoms. Pediatr Blood Cancer 2010;55:202–205. © 2010 Wiley‐Liss, Inc.