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Abdominal undifferentiated small round cell tumor with unique translocation (X;19)(q13;q13.3)
Author(s) -
Yustein Jason T.,
Rednam Surya,
Bertuch Alison A.,
Goss John A.,
Brandt Mary L.,
Eldin Karen,
Lu Xinyan,
Hicks John
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22437
Subject(s) - chromosomal translocation , medicine , pathology , abdominal mass , diaphragm (acoustics) , capsule , ultrastructure , tumor cells , cancer research , gene , biology , genetics , physics , botany , acoustics , loudspeaker
We describe a male with a large abdominal mass, most likely originating from the liver, with capsule rupture and tumor dissemination into the abdominal cavity. Adherence of the tumor to the diaphragm and lower right colon also were noted. A comprehensive evaluation of the mass revealed no tumor‐defining histopathologic, immunocytochemical, ultrastructural, cytogenetic, or translocation features. The malignant tumor was found to have a novel translocation (X;19)(q13;13.3), which has not been reported in small round cell tumors of childhood or adults. The final diagnosis rendered was an undifferentiated small round cell tumor of uncertain cell of origin. Pediatr Blood Cancer 2010;54:1041–1044 © 2010 Wiley‐Liss, Inc.