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Orbital sarcoma with metastases at diagnosis: A report from the soft tissue sarcoma committee of the Children's Oncology Group
Author(s) -
Huh Winston W.,
Anderson James R.,
Rodeberg David,
Teot Lisa,
Yock Torunn,
Raney R. Beverly
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22434
Subject(s) - medicine , rhabdomyosarcoma , blood cancer , sarcoma , soft tissue , soft tissue sarcoma , bone marrow , alveolar rhabdomyosarcoma , alveolar soft part sarcoma , cancer , radiology , pathology
Abstract We reviewed clinicopathologic features and treatment outcomes in seven patients diagnosed with Stage 4/Group IV orbital sarcoma and treated on IRSG protocols I–III. Three patients had embryonal rhabdomyosarcoma (RMS), and two patients each had alveolar RMS or unclassified sarcoma. Median age at diagnosis was 1.8 years (range 0.2–6.9 years). All patients had bone marrow involvement, including six with normal complete blood count at diagnosis. Cerebrospinal fluid was normal in six patients. Three patients survived >5 years, including one with local recurrence. In conclusion, further study is needed to determine necessity of bone marrow and CSF examination in orbital sarcoma patients. Pediatr Blood Cancer 2010;54:1045–1047 © 2010 Wiley‐Liss, Inc.