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A prospective evaluation of the prevalence of symptomatic von Willebrand disease (VWD) in a pediatric primary care population
Author(s) -
Bowman M.,
Hopman W.M.,
Rapson D.,
Lillicrap D.,
Silva M.,
James P.
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22429
Subject(s) - medicine , von willebrand disease , pediatrics , blood cancer , disease , population , von willebrand factor , cancer , platelet , environmental health
The prevalence of von Willebrand disease (VWD) is reported as ∼1%; however, these estimates were not based on individuals with significant symptoms. Four thousand five hundred ninety‐two unselected parents/children were asked: “Does your child have a problem with bleeding/bruising?”; 223 (5%) answered yes, 41 of whom were administered the validated Pediatric Bleeding Questionnaire and had VWF testing. Five were diagnosed with VWD (three type 1, one type 2A, one type 2B). The prevalence of bleeding/bruising in a general pediatric population is 5%; the prevalence of symptomatic VWD at the level of pediatric primary care is at least 1 in 1,000. Pediatr Blood Cancer 2010;55:171–173. © 2010 Wiley‐Liss, Inc.