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Kawasaki disease preceding haemophagocytic lymphohistiocytosis: Challenges for developing world practitioners
Author(s) -
Hendricks Marc,
Pillay Shakti,
Davidson Alan,
De Decker Rik,
Lawrenson John
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22422
Subject(s) - kawasaki disease , medicine , blood cancer , rash , hemophagocytic lymphohistiocytosis , histiocyte , disease , pediatrics , gamma globulin , immunology , dermatology , cancer , pathology , antibody , artery
Kawasaki disease (KD) is a recognised precipitant of haemophagocytic lymphohistiocytosis (HLH). Although KD has been previously described in the developing world, there are no reported cases of KD preceding HLH. We report a case of a child with a persistent rash and unremitting fever consistent with the diagnosis of KD, who was found to have HLH, after intravenous gamma globulin failed to produce a clinical response. The diagnosis was made using the revised diagnostic criteria for HLH from the Histiocyte Society (1994). She fulfilled six of the eight clinical and laboratory criteria needed to make the diagnosis. Pediatr Blood Cancer 2010;54:1023–1025 © 2010 Wiley‐Liss, Inc.