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Diffuse central nervous system protoplasmic astrocytoma
Author(s) -
Manley Sue,
Crooks Daniel,
Artingstall Libby,
Buxton Neil,
Appleton Richard,
Riordan Andrew,
Cleary Gavin,
Pizer Barry
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22402
Subject(s) - medicine , astrocytoma , pathology , parenchyma , lesion , presentation (obstetrics) , biopsy , protoplasm , central nervous system , glioma , radiology , biology , biochemistry , cancer research , cytoplasm
Protoplasmic astrocytoma is an extremely rare form of grade II low grade glioma which usually presents as a discrete mass lesion. We describe a 3‐year‐old female with diffuse protoplasmic astrocytoma with parenchymal involvement and leptomeningeal spread. This tumour proved extremely difficult to diagnose and followed a progressive course. Three superficial biopsies did not give the diagnosis and this was only confirmed 8 months from presentation from a larger fourth biopsy taken deeper from the cerebellum. To our knowledge this case represents the distinct presentation of protoplasmic astrocytoma presenting as extensive diffuse meningeal disease. Pediatr Blood Cancer 2010;54:768–769. © 2009 Wiley‐Liss, Inc.