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The role of myeloablative chemotherapy with autologous hematopoietic cell rescue in central nervous system germ cell tumors
Author(s) -
Bouffet Eric
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22376
Subject(s) - medicine , germinoma , chemotherapy , context (archaeology) , germ cell tumors , oncology , radiation therapy , germ cell , refractory (planetary science) , paleontology , biochemistry , biology , chemistry , physics , astrobiology , gene
This review of the experience of high dose chemotherapy in patients with recurrent or refractory intracranial germ cell tumor confirms that sustained tumor control can be achieved with this modality both in germinoma and non‐germinomatous germ cell tumors. Data from cooperative groups in Europe and North America suggest that the success rate is higher among patients with recurrent germinoma. The role of adjuvant radiation in that context remains unclear. These promising results have led some cooperative groups to incorporate in their protocols a high dose chemotherapy component for newly diagnosed patients with high‐risk features or poor response to initial chemotherapy. Pediatr Blood Cancer 2010;54:644–646. © 2010 Wiley‐Liss, Inc.