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Ifosfamide‐induced encephalopathy and movement disorder
Author(s) -
Ames Bethany,
Lewis Lionel D.,
Chaffee Sara,
Kim Julie,
Morse Richard
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22361
Subject(s) - ifosfamide , medicine , encephalopathy , neurotoxicity , toxicity , chemotherapy , oncology , pharmacology , cisplatin
Ifosfamide is a widely used chemotherapeutic agent for the treatment of a broad spectrum of solid tumors. CNS toxicity is a well‐described side effect of ifosfamide, but the mechanism of ifosfamide‐induced neurotoxicity remains poorly defined. We present two pediatric cases of hemiballismic limb movements in the setting of ifosfamide‐associated encephalopathy. To our knowledge, there have been no prior reports of ifosfamide‐induced hemiballism in pediatric patients. One of our patient's encephalopathy and abnormal movements may have improved after the administration of methylene blue and thiamine. Pediatr Blood Cancer 2010;54:624–626. © 2009 Wiley‐Liss, Inc.