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Central nervous system involvement at the time of presentation in acute promyelocytic leukemia
Author(s) -
Collins Chelsea,
Knoderer Holly
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22348
Subject(s) - medicine , acute promyelocytic leukemia , central nervous system , cerebrospinal fluid , presentation (obstetrics) , lumbar puncture , acute leukemia , chemotherapy , leukemia , disease , incidence (geometry) , pathology , surgery , retinoic acid , chemistry , physics , optics , gene , biochemistry
Central nervous system (CNS) involvement is rarely observed in acute promyelocytic leukemia (APML). Most cases of CNS involvement occur at relapse rather than at presentation. Because of the extremely low incidence of CNS disease, diagnostic lumbar puncture is not routinely required and prophylactic intrathecal chemotherapy is not routinely administered. Here, we describe a teenage patient with newly diagnosed APML, chloromas, and symptomatic CNS involvement confirmed by MRI and cerebrospinal fluid (CSF) findings. Pediatr Blood Cancer © 2009 Wiley‐Liss, Inc.