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Low dose, oral epsilon aminocaproic acid for renal papillary necrosis and massive hemorrhage in hemoglobin SC disease
Author(s) -
Gabrovsky Alexander,
Aderinto Abimbole,
Spevak Melissa,
Vichinsky Elliot,
Resar Linda M.S.
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22295
Subject(s) - medicine , renal papillary necrosis , necrosis , nephrectomy , disease , aminocaproic acid , surgery , epsilon aminocaproic acid , gastroenterology , kidney
Renal papillary necrosis in sickling hemoglobinopathies can lead to significant complications, including hemorrhage, obstruction, and infection. Despite its frequency, there are limited therapies for protracted hemorrhage. In the past, massive hemorrhage was managed with nephrectomy. Here, we report a patient with hemoglobin SC disease and prolonged, life‐threatening hemorrhage from papillary necrosis successfully treated with oral, low‐dose epsilon aminocaproic acid (EACA). Although further study is warranted, this case illustrates the need to consider EACA in the conservative management of renal papillary necrosis and significant hemorrhage in sickle cell hemoglobinopathies. Pediatr Blood Cancer 2010; 54:148–150. © 2009 Wiley‐Liss, Inc.