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Adipocytokines in relation to Hodgkin lymphoma in children
Author(s) -
Petridou Eleni Th.,
Dessypris Nick,
Panagopoulou Paraskevi,
Sergentanis Theodoros N.,
Mentis AlexiosFotios A.,
Pourtsidis Apostolos,
Polychronopoulou Sophia,
Kalmanti Maria,
AthanasiadouPiperopoulou Fani,
Moschovi Maria
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22294
Subject(s) - medicine , hodgkin lymphoma , adipokine , lymphoma , oncology , obesity , leptin
This case–control study aims to explore the association of serum adiponectin/leptin with childhood Hodgkin lymphoma (HL). Study participants were 75 children with histologically confirmed HL, registered in the Nationwide Registry for Childhood Haematological Malignancies and 75 age‐ and gender‐matched controls. Multiple conditional logistic regression analyses were performed, adjusting for sociodemographic and lifestyle parameters. Adiponectin levels were consistently higher among cases in all models with ORs >1.25; 95% CIs ranging from 0.9 to 1.8 and P ‐values from 0.09 to 0.20. By contrast, there was no association of serum leptin with HL. In conclusion, elevated serum adiponectin might be a risk factor for childhood HL. Pediatr Blood Cancer 2010;54:311–315. © 2009 Wiley‐Liss, Inc.