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Paediatric presentation of familial cerebral cavernoma
Author(s) -
Holme Harriet,
Nanduri Vasanta
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22288
Subject(s) - medicine , presentation (obstetrics) , headaches , central nervous system , hemangioma , parenchyma , neurology , pediatrics , blood cancer , family history , pathology , surgery , cancer , psychiatry
We report the case of a 13‐year‐old male who presented with headaches and was presumed to have a brain tumour. He was subsequently found to have multiple cerebral cavernomas with haemorrhage and positive family history. We review the literature on familial cavernomas. Cerebral cavernous malformations (CCMs) are characterized by abnormally enlarged capillary cavities without intervening brain parenchyma [Verlaan et al. Neurology 2005; 65:1982–1983] that may involve any part of the central nervous system. Focal neurologic deficit and haemorrhage occur in 45% of children, higher than in adults [Stoeter. Neurosurg Rev 2001; 24]. Paediatric patients with symptomatic cavernous malformations should be treated surgically because of the risk of haemorrhage [Lee et al. Child's Nervous Syst 2008; 24:321–327]. Pediatr Blood Cancer 2010;54:468–469. © 2009 Wiley‐Liss, Inc.