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Critical illness polyneuropathy: A rare but serious adverse event in pediatric oncology
Author(s) -
Charisius Jorma,
Stiefel Martina,
Merkel Nick,
Kornhuber Malte,
Haase Roland,
Kramm Christof Maria
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22287
Subject(s) - medicine , sepsis , mechanical ventilation , polyneuropathy , critical illness polyneuropathy , multifocal motor neuropathy , blood cancer , rhabdomyolysis , intensive care medicine , cancer , critical illness , critically ill , mismatch negativity , electroencephalography , psychiatry
Critical illness polyneuropathy (CIP) may aggravate sepsis and multiorgan dysfunction in pediatric oncology patients characterized by quadriparesis and difficult weaning from mechanical ventilation. Here, we report on an adolescent patient with acute lymphoblastic T‐cell leukemia who developed critical illness neuropathy after an episode of sepsis with need for mechanical ventilation and intravenous catecholamines. Differential diagnoses like vincristine‐induced polyneuropathy, anterior lumbosacral radiculopathy (ALR), Guillain–Barré syndrome, and chronic inflammatory demyelinating polyneuropathy — all occurring in pediatric patients with acute leukemia — are discussed. Pediatr Blood Cancer 2010; 54:161–165. © 2009 Wiley‐Liss, Inc.