Premium
Cytomegalovirus infection mimicking juvenile myelomonocytic leukemia showing hypersensitivity to granulocyte–macrophage colony stimulating factor
Author(s) -
Moritake Hiroshi,
Ikeda Toshio,
Manabe Atsushi,
Kamimura Sachiyo,
Nunoi Hiroyuki
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22253
Subject(s) - juvenile myelomonocytic leukemia , medicine , granulocyte macrophage colony stimulating factor , cytomegalovirus , immunology , granulocyte , leukemia , macrophage , virology , virus , cytokine , herpesviridae , viral disease , biology , haematopoiesis , genetics , stem cell , in vitro
We describe an infant with cytomegalovirus (CMV) infection presenting as transient myeloproliferation resembling juvenile myelomonocytic leukemia (JMML). The patient fulfilled the international diagnostic criteria of JMML, including hypersensitivity to granulocyte–macrophage colony‐stimulating factor (GM‐CSF). Viral studies using serologic assays and polymerase chain reaction (PCR) were positive for CMV. Clinical symptoms disappeared and laboratory values returned to normal without specific treatment within 1 year. Follow‐up showing a decrease in viral titers suggested CMV infection as an etiologic factor for the development of myeloproliferative features. We conclude that the CMV infection transiently induced abnormal myelopoiesis in this infant. Pediatr Blood Cancer 2009; 53:1324–1326. © 2009 Wiley‐Liss, Inc.