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Subcutaneous anti‐D treatment of idiopathic thrombocytopenic purpura in children
Author(s) -
Kjaersgaard Mimi,
Edslev Pernille Wendtland,
Hasle Henrik
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22248
Subject(s) - medicine , thrombocytopenic purpura , chills , platelet , subcutaneous injection , gastroenterology , limiting , pediatrics , mechanical engineering , engineering
We investigated the effect of subcutaneous anti‐D IgG as platelet enhancing therapy in children with idiopathic thrombocytopenic purpura (ITP). Twenty‐three children were treated with subcutaneous anti‐D 50 µg/kg. The median platelet count increased from 7 × 10 9 to 31 × 10 9 /L on day 3 ( P < 0.01). The median decline in hemoglobin was 1.3 g/dl. Two children experienced minor fever and chills within 24 hr of treatment. Pain at the injection site was common but self‐limiting with no effect on activity level. These results suggest subcutaneous anti‐D IgG 50 µg/kg as an effective and well‐tolerated treatment option in childhood ITP. Pediatr Blood Cancer 2009; 53:1315–1317. © 2009 Wiley‐Liss, Inc.