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Role of Wnt inhibitory factor‐1 and Wnt/wingless signaling in choroid plexus tumors
Author(s) -
Tomm Manuel,
Koch Arend,
Mertsch Sonja,
Wrede Brigitte,
Jeibmann Astrid,
Wolff Johannes,
Paulus Werner,
Hasselblatt Martin
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22201
Subject(s) - wnt signaling pathway , choroid plexus , cancer research , medicine , beta catenin , lrp5 , microbiology and biotechnology , inhibitory postsynaptic potential , pathology , signal transduction , biology , endocrinology , central nervous system
Little is known on pathways involved in the pathogenesis of choroid plexus tumors (CPTs). The finding of overexpression of Wnt inhibitory factor‐1 (Wif‐1) prompted us to investigate the functional role of Wif‐1 as well as nuclear accumulation of beta‐catenin in CPT. In Z310 neoplastic choroid plexus epithelial cells, silencing of Wif1 expression increased proliferative activity not associated with increased canonical Wnt signaling. Nuclear beta‐catenin accumulation was also lacking in a series of 16 CPT. In conclusion, our data show that Wif‐1 inhibits proliferation of neoplastic choroid plexus epithelial cells, but argue against a role of canonical Wnt/wingless signaling in CPT. Pediatr Blood Cancer 2009;53:1152–1155. © 2009 Wiley‐Liss, Inc.