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Vincristine: Can its therapeutic index be enhanced?
Author(s) -
Moore Andrew,
Pinkerton Ross
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22161
Subject(s) - medicine , vincristine , index (typography) , therapeutic index , oncology , pharmacology , chemotherapy , world wide web , drug , cyclophosphamide , computer science
Vincristine is one of the most widely used and more effective drugs in paediatric oncology. The dose‐limiting toxicity of neuropathy, lack of proven neuroprotective measures and an incomplete understanding of the pharmacokinetics and pharmacogenetics of vincristine have limited its therapeutic potential. Recent advances in the understanding of vincristine pharmacokinetics and pharmacogenetics, and potential methods of preventing neurotoxicity are reviewed which could enable dose escalation and dose individualisation in order to enhance the therapeutic index. Pediatr Blood Cancer 2009; 53:1180–1187. © 2009 Wiley‐Liss, Inc.