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Inflammatory BCG adenitis associated with immune reconstitution following allogeneic haematopoietic stem cell transplant in infancy
Author(s) -
Searle E.,
Patel H.,
Vilar F.J.,
Gharib M.,
Turner A.J.,
Batra G,
Wynn R.F.
Publication year - 2010
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22143
Subject(s) - medicine , haematopoiesis , stem cell , immune system , adenitis , antimycobacterial , immunology , disease , hematopoietic stem cell transplantation , tuberculosis , pathology , mycobacterium tuberculosis , genetics , biology
We describe four cases of a localized, granulomatous reaction to BCG including ipsilateral painful, suppurative lymphadenopathy associated with donor immune reconstitution following allogeneic haematopoietic stem cell transplant performed in infancy and preceded by uneventful, routine BCG immunisation. The management of the inflammatory disease in these cases with surgery, antimycobacterial chemotherapy and steroids, is discussed. Pediatr Blood Cancer 2010; 54:166–169. © 2009 Wiley‐Liss, Inc.