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WT1 expression at diagnosis does not predict survival in pediatric aml: A report from the Children's Oncology Group
Author(s) -
Noronha Suzie A.,
Farrar Jason E.,
Alonzo Todd A.,
Gerbing Robert B.,
Lacayo Norman J.,
Dahl Gary V.,
Ravindranath Yaddanapudi,
Arceci Robert J.,
Loeb David M.
Publication year - 2009
Publication title -
pediatric blood and cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.116
H-Index - 105
eISSN - 1545-5017
pISSN - 1545-5009
DOI - 10.1002/pbc.22142
Subject(s) - medicine , oncology , myeloid leukemia , pediatric oncology , overall survival , wilms' tumor , leukemia , cancer research , cancer
WT1 is a transcription factor that is aberrantly overexpressed in acute and chronic leukemias. Overexpression of WT1 in pediatric acute myeloid leukemia has been reported, but the prognostic significance is unclear because sample sizes in these studies have been relatively small. WT1 expression was measured by quantitative RT‐PCR in samples obtained at diagnosis from 155 pediatric AML patients treated on a cooperative group protocol. Neither overall survival nor event‐free survival was correlated with WT1 expression. Pediatr Blood Cancer 2009;53:1136–1139. © 2009 Wiley‐Liss, Inc.